Advisor - In Vitro Pharmacology, Obesity Research (Boston)

Company: Eli Lilly and Company
Location: Boston
Posted on: February 1, 2025

Job Description:

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is $133,500 - $217,800.The Diabetes, Obesity and Complications Therapeutic Area (DOCTA) of Eli Lilly and Company focuses on the discovery of biologic, small molecule, and genetic therapeutics for the treatment of diabetes, obesity, and associated complications.We are seeking a skilled, motivated, and versatile scientist who can help advance a highly collaborative, successful drug discovery and development team in the Obesity research group in Boston, MA. The ideal candidate will have a deep understanding of the biology and physiology of obesity, current anti-obesity treatments and a strong background in cell-based functional assays and biochemical assays. In this position, the candidate will assist in assay development to validate new targets and/or characterize the in vitro function of novel therapeutics, playing a crucial role in supporting our comprehensive discovery efforts and ongoing pipeline projects focused on anti-obesity therapeutics. The candidate's ability to make data-driven decisions and recommendations will allow them to make a significant impact on our obesity pipeline. Additionally, the candidate will be responsible for establishing critical laboratory capabilities and collaborating with other scientists within and across departments to achieve both project and departmental goals.Are you ready to make a meaningful impact on the future of obesity therapeutics while advancing your career in a dynamic and collaborative research environment? Apply today to be part of this innovative team at Lilly!Key Responsibilities:

• Be hands-on in the laboratory to design, develop and implement cellular and/or biochemical assays to assess new targets or screen therapeutics, making critical contributions to drug discovery programs for the treatment of obesity and metabolic diseases. Potentially lead a drug discovery program.
• Provide scientific and technical ability to assess new target and therapeutic hypotheses for the obesity group, applying expertise in protein biochemistry, proteomics and molecular/cellular biology and in vivo pharmacology.
• Function independently, work within a team-oriented lab environment and within cross-functional project teams.
• Requirement for accurate record keeping, independent data analysis, and reporting of data in written and oral formats. Will perform work in full compliance with Lilly Research Policies and complete all required training activities in the timeframe specified.
• Support the implementation of new assay technologies.
• Provide supervision to 1-2 scientists, provide mentoring, performance evaluation and career development.Technical/Scientific Skills:
  • Strong background in cardiometabolic diseases.
  • Aseptic cell culture techniques with mammalian cells.
  • Transient transfections and generation of stable cell lines.
  • Development of functional assays from recombinant or native cells or biochemical assays.
  • Screening of novel therapeutics in 96-/384-well plate formats at a single concentration or in a concentration/response manner.
  • Strong knowledge of basic pharmacology (e.g. concentration/response curves, determination of binding affinity, potency, Hill's slope and in vitro efficacy). Drug mechanism of action studies.
  • Experience with colorimetric, luminescence and fluorescence-based readouts, including HTRF. Proficient in operating plate readers.
  • Gene expression studies by qPCR, western blot and FACS techniques.Soft Skills:
    • Strong communication skills and experience presenting data to internal and external partners and teams.
    • Strong interpersonal skills and sustained tendency for collaboration.
    • Ability to conduct independent data analysis, interpret and communicate data output, and troubleshoot as needed.
    • Ability to follow accurate record keeping in electronic lab notebook.
    • Attention to detail and ability to prioritize work on multiple projects, timelines and company goals and manage ambiguity.
    • Eager to grasp fundamental principles, swiftly acquire new abilities, and adjust to novel challenges.
    • Demonstrate initiative and appropriate risk taking.Minimum Qualifications:
      • Ph.D. in biology, pharmacology, biochemistry or related field with 2+ years of postdoctoral training or industry experience.Additional Preferences:
        • Understanding of primary complications of obesity such as chronic kidney disease and cardiovascular disorders.
        • Expertise with new target proposals.
        • Exposure to multiple therapeutic target classes (e.g. membrane receptors including G-Protein Coupled Receptors or GPCRs, enzymes, transporters, etc.) and multiple modalities (small molecules, peptides, antibodies, siRNAs, etc.)
        • Experience with CRISPR gene editing in in vitro systems and molecular biology overall.
        • Expertise with iPSCs, coculture and/or organoid culture systems.
        • Exposure to drug discovery in the context of pharma/biotech or through collaborations. Proficient in operating liquid handling robots and in assay automation.Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form () for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
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Keywords: Eli Lilly and Company, Newton , Advisor - In Vitro Pharmacology, Obesity Research (Boston), Other , Boston, Massachusetts