Research Scientist, Cell Engager Therapies In Vivo Pharmacologist
Company: Takeda Pharmaceutical
Location: Boston
Posted on: October 23, 2024
Job Description:
By clicking the "Apply" button, I understand that my employment
application process with Takeda will commence and that the
information I provide in my application will be processed in line
with Takeda's and . I further attest that all information I submit
in my employment application is true to the best of my
knowledge.Job DescriptionAbout the role:At Takeda, we are a
forward-looking, world-class R&D organization that unlocks
innovation and delivers transformative therapies to patients. By
focusing R&D efforts on four therapeutic areas and other
targeted investments, we push the boundaries of what is possible in
order to bring life-changing therapies to patients worldwide.Join
Takeda as a Research Scientist, Cell Engager Therapies In Vivo
Pharmacologist where you will be responsible for the discovery and
development of novel therapeutics in the T cell engager space
supporting new and ongoing pipeline programs. This is a fully
lab-based role where you will work with the in-vivo lead and and be
responsible for critical path activities. You will be asked to have
a strong foundation in in vivo models of cancer. As a key member of
the team, you will be responsible for new in vivo model
development, target validation, assessing therapeutic concepts of
various immune engager molecules and advancing development
candidates to IND. You will collaborate and demonstrate effective
communication and documentation of results. As part of the Oncology
Drug Discovery Unit, you will report to Associate Director In Vivo
Lead Cell Engager Therapies.How you will contribute:
- Development of animal models to test the biological efficacy of
therapeutic agents for oncology indications.
- Design and execute in vivo efficacy models in xenograft and PDX
models.
- Participate in analysis of in vivo studies to help establish PK
/ PD / efficacy relationships.
- Execute experiments with minimum supervision and deliver
comprehensive high quality data sets to enable decision
making.
- Ability to multi-task effectively and prioritize workload.
- Interpret results of complex experiments.
- Prepares and presents comprehensive technical or project
reports and formal presentations.
- Maintain laboratory notebooks and follow laboratory practices
in compliance.
- Demonstrate in-depth technical in vivo knowledge.
- Clarify requests and provide suggestions and put data into
context especially in context of study design and quality of
data.
- Be a in vivo SME on projects providing scientific feedback to
advance programs in a matrixed environment.
- Provide information to project teams to influence direction,
align with departmental goals and/or business.
- Conduct scientific presentations to internal audiences.
- Collaborate with others across sites, and act as scientific
resource for in vitro pharmacology.
- Strive towards expanding scientific knowledge in
immunology.
- Receive high level instructions on work; determine methods on
new assignments; demonstrated greater independence; may manage
interns.Minimum Requirements/Qualifications:
- MS with 4+ years' experience, or BS with 6+ years' of research
experience in lab setting working with animals.
- Experience in industry required, in animal facilities.
- Proficiency with in vivo efficacy rodent models, including
mouse syngeneic, xenograft and PDX models.
- Experimental skills, including mammalian tissue culture, in
vivo model development, drug administration by multiple routes (IV,
SQ, IP, PO, RO), and blood/tissue collection. Imaging experience is
highly desirable.
- Experience culturing and maintaining human tumor cell lines and
primary human cells, preferably T cells, with best practices in
tissue culture is critical.
- Hands -on basic experience with multi-color flow cytometry,
ELISA, MSD and other standard cell based and non-cell based
biochemical assays is desired.
- Use of scientific databases and application for data management
and data analysis (Graph Pad Prism, Soft Max Pro, Office 365,
FlowJo etc).
- Excellent team player with a can-do attitude with an ability to
thrive in a dynamic "biotech- like" environment and work in
cross-functional project teams.
- Self-motivated, collaborative with excellent time management
and organizational skills.
- Takeda's high-engagement culture is an important factor in our
success; we seek team members who will contribute to and further
strengthen that culture.More about us:At Takeda, we are
transforming patient care through the development of novel
specialty pharmaceuticals and best in class patient support
programs. Takeda is a patient-focused company that will inspire and
empower you to grow through life-changing work.Certified as a
Global Top Employer, Takeda offers stimulating careers, encourages
innovation, and strives for excellence in everything we do. We
foster an inclusive, collaborative workplace, in which our teams
are united by an unwavering commitment to deliver Better Health and
a Brighter Future to people around the world.#LI-SB1Takeda
Compensation and Benefits SummaryWe understand compensation is an
important factor as you consider the next step in your career. We
are committed to equitable pay for all employees, and we strive to
be more transparent with our pay practices. -For Location:Boston,
MAU.S. Base Salary Range:$108,500.00 - $170,500.00The estimated
salary range reflects an anticipated range for this position. The
actual base salary offered may depend on a variety of factors,
including the qualifications of the individual applicant for the
position, years of relevant experience, specific and unique skills,
level of education attained, certifications or other professional
licenses held, and the location in which the applicant lives and/or
from which they will be performing the job.---The actual base
salary offered will be in accordance with state or local minimum
wage requirements for the job location. -U.S. based employees may
be eligible for short-term and/ or long-term incentives. U.S. based
employees may be eligible to participate in medical, dental, vision
insurance, a 401(k) plan and company match, short-term and
long-term disability coverage, basic life insurance, a tuition
reimbursement program, paid volunteer time off, company holidays,
and well-being benefits, among others. U.S. based employees are
also eligible to receive, per calendar year, up to 80 hours of sick
time, and new hires are eligible to accrue up to 120 hours of paid
vacation. -EEO StatementTakeda is proud in its commitment to
creating a diverse workforce and providing equal employment
opportunities to all employees and applicants for employment
without regard to race, color, religion, sex, sexual orientation,
gender identity, gender expression, parental status, national
origin, age, disability, citizenship status, genetic information or
characteristics, marital status, status as a Vietnam era veteran,
special disabled veteran, or other protected veteran in accordance
with applicable federal, state and local laws, and any other
characteristic protected by law.LocationsBoston, MAWorker
TypeEmployeeWorker Sub-TypeRegularTime TypeFull time
Keywords: Takeda Pharmaceutical, Newton , Research Scientist, Cell Engager Therapies In Vivo Pharmacologist, Other , Boston, Massachusetts
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